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a large number of修饰可数名词。a large number of的意思是“大量的”。例句：A large number of books are missing from the library.图书馆的许多书不见了。
Number的用法
number的用法：
1、号码。可缩写No。这类结构通常不用冠词。
2、表示数目或数量，注意区别a number of与the number of。
3、用于习语in number和in numbers，两者均可表示“在数量上”。in number还有两个用法：一是表示“总共”，二是表示在动词或名词的“数”。
a large number of例句
1、 Dalian Bay: A large number of kelp rots, a large number of shellfish die, jellyfish disappear.
2、A departure of a large number of people.
3、second, a diverse population with a large number of subgroups;
4、A single mosquito can infect a large number of people.
5、The slaughter of a large number of animals.
6、Pingjiang Road has a large number of foreigners, almost equal to the number of domestic tourists.