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含义不同，be careful of表示“当心”、“留意”等意思；be careful with表示做某事时很小心或仔细的意思。careful的基本意思是“仔细的”、“小心的”，含有靠认真实践来避免错误的意味。
be careful of和with的区别
be careful of造句
Be careful of the dog，it sometimes bites people。当心那条狗，它有时候会咬人。
Be careful of that sinister man，He is dangerous。留意那个阴险的人，他很危险。
You must be careful of your health。你一定要注意你的健康。
be careful with造句
1、We have to be careful with fire.
2、be careful with the underlined parts.
3、Do be careful with this feature, however.
4、Always be careful with shell expansion and variable names.
5、Please be careful with the glass lamp, it's very delicate.
6、Do be careful with the experiment you're doing.
7、I told him that was my job, to be careful with descriptions.
8、Some heavily styled navigation items may look like banners, so be careful with these elements.