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mouse含有“老鼠、鼠标”等意思；而rat含有“老鼠、背叛、欺骗”等意思。mouse只能作名词使用；而rat既可以作名词使用，又可以作动词使用。当mouse的意思为“老鼠”时，其指代的是家鼠或小白鼠，该品种的老鼠，体型较小；当rat的意思为“老鼠”时，其指代的是大老鼠，该品种的老鼠，体型较大。
mouse的例句
Use the mouse to drag the icon to a new position.
用鼠标将图标拖到一个新的位置。
Click the left mouse button twice to highlight the program.
双击鼠标左键来加亮突出这个程序。
He was a weak little mouse of a man.
他是个懦弱无能的人。
A cat often plays with a mouse before the kill.
猫在咬死老鼠之前常常要耍弄它一番。
I held the mouse by its tail.
我抓着耗子的尾巴倒提起来。
rat的例句
The rats had been conditioned to ring a bell when they wanted food.
这些老鼠已经过训练，想吃食物时就会按铃。
Rats had gnawed through the cable.
老鼠把电缆咬断了。
Where I come from, you don't rat on your friends.
在我的老家，谁都不出卖朋友。
People think I'm sick for having a rat as a pet.
人们认为我养只耗子当宠物是变态。
The rats were controlled by poisoning.
用毒杀法使老鼠受到控制。